Bioactive Components from Agarwood Originating from Aquilaria crassna

Abstract:

In order to understand the chemical constituents of Aquilaria crassna, ten compounds were isolated from its agarwood. On the basis of spectral data, they were identified as 6,8-dihydroxy-2-(2-phenylethyl)-chromone (1), 6,8-dihydroxy-2-[2-(4-methoxyphenyl) ethyl]chromone (2), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-(2-phenylethyl)-7H-oxireno[f][1]benzopyran-7-one (3), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-[2-(4-methoxyphenyl)ethyl]-7H-oxireno[f][1]benzopyran-7-one (4), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-[2-(3-hydroxy-4-methoxyphenyl) ethyl]-7H-oxireno[f][1]benzopyran-7-one (5), oxidoagarochromone B (6), oxidoagarochromone C (7), (5S,6R,7S,8R)-2-[2-(3'-hydroxy-4'-methoxyphenyl)ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone (8), 6,7-cis-dihydroxy-2-(2phenylethyl)-5,6,7,8-tetrahydrochromone (9), N-trans-feruloyltyramine (10). Compounds 1-5 and 8-11 were isolated from agarwood of A. crassna for the first time. Compounds 1, 3, 4, 6, 7 and 11 showed inhibitory activities against acetylcholinesterase. Compound 4 had weak inhibitory effect on K-562 and SGC-7901 carcinoma cell lines, and compounds 1 and 3 showed inhibitory activity against BEL-7402 cells.