Abstract:Leptocybe invasa Fisher & La Salle is a serious disease for Eucalyptus. In order to understand physiological response of Eucalyptus to Leptocybe invasa damage, the damage degree and some inclusion contents in leaves of 24 Eucalyptus clones hazard by Leptocybe invasa were studied for continuous five months. According to the damage degree, all clones were divided into 3 types, such as high sensitive, middle resistance and high resistance. The results showed that the soluble protein and soluble sugar contents in leaves had no significant difference among three resistance types before the 24 Eucalyptus clones were damaged by Leptocybe invasa, while those in high sensitive and middle resistance clones leaves significantly increased after damaged. Contrasted to control, soluble protein and soluble sugar contents in high sensitive clones leaves significant increased with damage aggravation. The increment of inclusion contents in Eucalyptus clones leaves was in order as high sinsitive > middle resistant > high resistant. Therefore, it was suggested that the increment of inclusion contents in Eucalyptus clones leaves was an important physilogical response to damage of Leptocybe invasa.