Abstract:Hybridization of Paphiopedilum has been performed for more than 150 years and 20 262 hybrids had been registered in RHS until 1 July, 2009. The research progress and prospect of cross breeding of Paphiopedilum were reviewed, such as germplasm resources, hybrid registering, the method of cross breeding, the choice of hybridization parents, hybridization between Paphiopedilum and other genera, color heredity and the problem of cross breeding. The advice of breeding direction was also proposed according to the current situation of Paphiopedilum breeding in China.