Abstract:To improve the comprehensive utilization of Kadsura coccinea resources, the differential and highly enriched metabolic components of root, stem and leaf were analyzed by using wide range of targeted metabolomics techniques. The results showed that there were 642, 650 and 619 metabolites identified from roots, stems and leaves, respectively, in which phenolic acids, lipids, flavonoids and organic acids were dominant in quantity. There were 566 and 650 common metabolites in leaves and roots, stems and roots, respectively, of which 442 and 393 were significantly different metabolites, mainly including phenolic acids, flavonoids and lipids. Moreover, these differentially metabolites were significantly enriched in pathways of phenylpropane biosynthesis, flavone and flavonol biosynthesis. The total and secondary metabolites abundances were in the order of leaf > root > stem. The accumulation of phenolic acids, flavonoids and lipids in leaves and phenolic acids in stems were significantly higher than those in roots; while the abundance of amino acids and their derivatives, terpenoids, lignans, coumarins and alkaloids were significantly up-regulated in roots. Therefore, there were a large number of common components in roots, stems and leaves of K. coccinea. Phenolic acids, flavonoids and lipids in leaves and stems were highly enriched, and several bioactive compounds, such as neochlorogenic acid, chlorogenic acid and quercetin, were highly abundant and have high utilization value.

Abstract:In order to understand the chemical constituents from Lentopodium lenotopodioides (Asteraceae), eight phenylpropanoids were obtained from its whole herbs by multiple chromatographic separation techniques. On the basis of spectral data, their structures were identified as dihydrodehydrodiconiferyl alcohol 4-O-β-d-glucoside (1), dihydrodehydrodiconiferyl alcohol 9-O-β-d-glucoside (2), dehydrodiconiferyl alcohol 9-O-β-d-glucoside (3), dehydrodiconiferyl alcohol 9-methyl ether-4-O-β-d-glucoside (4), (-)-pinoresinol 4-O-β-d-glucoside (5), (-)-medioresinol 4-O-β-d-glucoside (6), citrusin C (7), and caffeic acid (8). Compounds 2-7 were obtained from this species for the first time. The inhibitory rates of these compounds toward α-glucosidase were less than 50% at the concentration of 500 μmol L-1.

Abstract:In order to understand the chemical constituents of Mangifera indica L., 13 compounds were isolated from 75% ethanol extract of mango leaves. On the basis of NMR and MS determination, they were identified as (-)-secoisolariciresinol-9′-O-β-D-glucopyranoside (1), 7S,8R-erythro-4,7,9-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9′-O-β-D-glucopyranoside (2), 7R,8R-threo-4,7,9-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9′-O-β-D-glucopyranoside (3), (7R/S,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-enzofuranpropanol 9′-O-β-D-glucopyranoside (4), citrusin D (5), syringin (6), 2,6-dimethoxy-4-hydroxyphenyl-1-O-β-D-glucopyranoside (7), protocatechuic acid (8), gallic acid (9), methyl gallate (10), ethyl gallate (11), 4,5-dihydroxy-3-methoxy benzoic acid (12), and daucosterol (13). Among them, Compounds 1-7 and 12 were obtained from Mangifera genus for the first time.

Abstract:Four glycosides, (2R)-2-O-β-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)- one (1), (2R)-2-O-β-D-glucopyranosyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one (2), pinoresinol-4-O-β-D-apiosyl-(1→2)-β-D-glucopy-ranoside (3), and uridine, were isolated from the roots of Baphicacanthus cusia (Nees) Bremek. All these constituents are reported from this plant for the first time. The presence of benzoxazinoids (1 and 2) is in agreement with the anti-inflammatory effect of this plant.