Abstract:In order to understand the chemical composition of Ainsliaea glabra, ten compounds were isolated from petroleum ether extraction fraction of 90% ethanol extract by silica gel, sephadex LH-20 gel column chromatography, semi-preparative high-performance liquid chromatography. Based on spectral data, their structures were identified as pinerenol diisovalerate (1), 3β-hydroxy-11α,13-dihydro-costunolide (2), matricarin (3), taraxasteryl acetate (4), betulyl alcohol (5), 27-hydroxyolean-12-en-28-oic acid (6), morolic acid acetate (7), (-)-loliolide (8), butyl benzoate (9), and E-phytenal (10). Compound 1 was a new structural compound. Compounds 3 and 7 were isolated from Ainsliaea genus for the first time. Compounds 2-7 and 9 were first reported in the A. glabra. The results of antibacterial activity test showed that compounds 1, 2 and 8 had certain inhibitory effects on Staphylococcus aureus with MIC values of 31.2, 25.0, and 21.8 μg/mL, and compounds 1 and 3 had potential inhibitory effect on Candida albicans with MIC values of 1.9 and 3.9 μg/mL, respectively.
