Phenolic Glycosides from Eurya chinensis and Their Cytotoxic Activities Against Nasopharyngeal Carcinoma Cells

Abstract:

To clarify the chemical constituents and their biological activities of Eurya chinensis, eleven compounds were isolated from its MeOH extract by various column chromatography methods, and the anti-proliferative activity of compounds against human nasopharyngeal carcinoma cells (5-8F) were evaluated. Basis on spectral data, their structures were identified as isoastinlbin (1), 3,5,7-trihydroxychromone-3-O-α-L-arabino-pyranoside (2), 1-O-trans-cinnamoyl-β-D-glucopyranose (3), 2-(4-hydroxyphenyl)ethyl-6-O-(E)-cinnamoyl-β-D-glucopyranoside (4), eutigoside D (5), 6-O-coumaroyl-1-O-[2-(3,4-dihydroxyphenyl)ethyl]-β-D-glucopyranoside (6), eutigoside A (7), 2-(4-hydroxypheny)ethyl-[6-O-(E)-caffeoyl]-β-D-glucopyranoside (8), grayanoside A (9), 4-hydroxyphenylethyl-1-O-β-D-[6'-O-(4-hydroxybenzoyl)]-glucopyranoside (10), benzyl-4'-hydroxybenzoyl-3'-O-β-D-glucopyranoside (11). Compound 4 was isolated from natural resources for the first time, while the compounds 2- 4, 8- 11 were obtained from the genus Eurya for the first time. The compound 10 showed moderate inhibitory activity on the proliferation of 5-8F cells by MTT method.

Key words:Eurya;E. chinensis;Phenolic glycoside;5-8F cell;Cytotoxicity