HE Jianmin
School of Resource and Environment, Baoshan University, Baoshan 678000, Yunnan, ChinaYAN Yuanfeng
School of Bioengineering, Zunyi Medical University, Zhuhai 519041, Guangdong, ChinaYIN Tianpeng
School of Bioengineering, Zunyi Medical University, Zhuhai 519041, Guangdong, ChinaTo understand the alkaloidal constituents of Aconitum episcopale, an Aconitum species endemic to China, and their toxicity against rat cardiomyocyte H9c2 cells, ten diterpenoid alkaloids were extracted from its roots. Based on physical and chemical properties and spectral data, their structures were identified as yunaconitine (1), crassicauline A (2), vilmorrianine C (3), vilmorrianine A (4), forestine (5), falconeridine (6), 14-O-acetylsachaconitine (7), sachaconitine (8), chasmanine (9) and vilmotenitine A (10), were isolated and identified from A. episcopale roots. Compounds 5, 6 and 10 were isolated from this species for the first time. The median inhibition concentrations of compounds 1- 4, 6- 7 and 9- 10 on H9c2 cells ranged from 163.8 to 341.6 μg/mL, showing the alkaloids in A. episcopale had toxic effects on H9c2 cells.
何健民,严园锋,尹田鹏.紫草乌中生物碱成分及其对H9c2细胞毒性研究[J].热带亚热带植物学报,2023,31(3):395~400
Copy
