Chemical Constituents and Antioxidant Activities of Garcinia xanthochymus Leaves

Abstract:

To study the chemical constituents of Garcinia xanthochymus leaves, nineteen compounds were obtained from its leaves by UPLC-QTOF-MS, including bioflavonoids, flavonoids and phloroglucinols. Five compounds were isolated from 80% methanol extract of leaves by chromatographic methods. On the basis of spectral data, they were identified as dihydrokaempferol (1), dulcisbiflavonoid A (2), bilobetin (3), mono-[2-(4-carboxy-phenoxycarbonyl)-vinyl] ester (4) and kaempferol (5). Compounds 1 and 2 were isolated from G. xanthochymus for the first time, while compounds 3 and 4 were isolated from genus Garcinia for the first time. Compounds 1 and 5 showed antioxidant activity with IC₅₀ of 146.8 and 39.0 μg/mL, respectively.

Key words:Garcinia xanthochymus;Leaf;Chemical constituent;Flavonoid;Antioxidant activity