Metabolites of Fusarium tricinctum, An Endophytic Fungus Isolated from Ningguo Peucedanum praeruptorum on Solid Fermentation

Abstract:

To investigate the chemical metabolites from Fusarium tricinctum, an endophytic fungus isolated from Ningguo Peucedanum praeruptorum, 14 compounds were isolated from solid fermentation and purified by silica gel column chromatography, MPLC, and preparative liquid chromatography. Based on data of MS and NMR, their structures were identified as fungerin (1), fusagerins F (2), 6-[(3R)-3-hydroxybutan-2-yl]-5-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (3), 6-[(3S)-3-hydroxybutan-2-yl]-5-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (4), 6α-chlamydosporol (5), 6β-chlamydosporol (6), (3R,4R)-(-)-4-hydroxymellein (7), (3R)-(-)-8-hydroxymellein (8), enniatin B (9), enniatin B1 (10), enniatin A1 (11), enniatin A (12), enniatin B3 (13), enniatin B2 (14). All these compounds are isolated from this endophytic fungus for the first time. The cytotoxicity assay of all compounds did not show anti-tumor activities.

Key words:Ningguo Peucedanum praeruptorum;Endophytic fungus;Metabolite;Anti-tumor activity