LC-MS Guided Isolation of Chemical Constituents from Pseuderanthemum latifolium and Their Biological Activities

Abstract:

In order to study the chemical constituents from Pseuderanthemum latifolium and their biological activities, two main compounds were isolated from the EaOAc fraction and identified as lupeol (1) and stigmasterol (2) by using LC-MS guided isolation. In vitro activity screening, all these compounds showed moderate anti-MRSA activities but no neuroprotective effects. This is the first report about the chemical constituents from P. latifolium and their biological activities, which would provide scientific basis to the development and utilization of P. latifolium.

Key words:Pseuderanthemum latifolium;LC-MS;Lupeol;Stigmasterol