Abstract:PPR proteins are one of the largest protein families in terrestrial plants, both on category and volume. The main functions of PPRs were involved in post-transcriptional modifications and editing of specific single-stranded RNAs in the nucleus and organelles via their localization in various organelles. PPRs play important roles in series events of plant growth and development. Mutants of most PPR protein-encoding genes exhibit abnormal developmental phenotypes, such as embryonic lethality, developmental retardation, and greening delays. The recent research advances of PPRs in classification, localization, RNA modification mechanisms and their functions on regulating growth and development of plants were summarized, and the studies on functional area and participating regulatory network of PPR in plants was prospected.