Abstract:In order to understand the nematicidal activities of amide alkaloids from the seeds of Clausena lansium, ten amide alkaloids were isolated by comprehensive chromatographic techniques. On the basis of spectral data, their structures were identified as:N-methyl-cinnamamide (1), clausenalansamide A (2), 3-dehydroxy-3-methoxyl-clausenalansamide A (3), clausenalansamide B (4), lansiumamide B (5), N-2-phenylethyl-cinnamamide (6), 2'-dehydroxy-2'-oxo-clausenalansamide B (7), lansamide-7 (8), homoclausenamide (9), 1,5-dihydro-5-hydroxy-1-methyl-3,5-diphenyl-2H-pyrrol-2-one (10). Among them, compounds 3, 7 and 10 were new natural products. Meanwhile, the nematicidal activity against Panagrellus redivivusl was tested for the first time. All of them showed the nematicidal activity, and compounds 2, 3, 5 and 8 presented stronger activities than dichlorofenthion, providing scientific evidence for the development of new pesticide.