Chemical Constituents from Gochnatia decora Barks and Their Anti-inflammatory Activities

Abstract:

In order to clarify the chemical constituents and their anti-inflammatory activities of Gochnatia decora,eleven compounds were isolated from the petroleum ether fraction of methanol extracts from the barks of G.decora.These compounds were identified as friedelin (1),friedelinol (2),oleanolic acid (3),oleanene (4),stigmasterol (5),β-sitosterol (6),palmitic acid (7),n-pentadecanoic acid (8),l-O-myristoylglycerol (9),methyl 4-hydroxybenzoate (10),and methyl gallate (11).All the compounds were obtained from the genus Gochnatia for the first time.The compounds 1,3 and 4 displayed significantly high inhibitory activities against NO production (IC₅₀<10 μmol L^-1),while 2,3 and 4 exhibited moderate neutrophil elastase (NE) inhibitory activities by the assay of LPS-induced NO production in RAW264.7 cells and inhibition of NE,respectively.

Key words:Gochnatia decora;Chemical constituent;Triterpenoids;Anti-inflammatory activity