Studies on Chemical Compositions and Cytotoxicities from Roots of Aphanamixis grandifolia Bl.

Abstract:

In order to understand the antitumor active ingredients of Aphanamixis grandifolia Bl., nine compounds were isolated from 95% ethanol extract of its roots. They were identified as 7-hydroxycadalene (1), dregeana-1 (2), 4-oxopinoresinol (3), 4-ketopinoresinol (4), 6-deoxyjacareubin (5), schleicheol 1 (6), stigmasterol (7), β-sitosterol (8), and daucosterol (9) on the basis of spectral data. Compounds 1-6 were isolated from the genus Aphanamixis for the first time, and the ¹³C NMR spectral data of compound 1 was reported for the first time. Compounds 1 and 5 showed inhibition of the proliferation of K562 cell line, and compounds 1,5 and 6 possessed inhibitory activity against SGC-7901 cell line.

Key words:Meliaceae;Aphanamixis grandifolia Bl.;Chemical constituent;Antitumor activity