Chemical Constituents from Twigs of Aglaia testicularis C. Y. Wu

Abstract:

Eleven compounds were isolated from the twigs of Aglaia testicularis C. Y. Wu (Meliaceae) by means of chromatographic technology. On the basis of spectral data, their structures were identified as phlogacantholide B (1), phlogacanthoside A (2), (E)-aglawone (3), eichlerianic acid (4), shoreic acid (5), 3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene (6), stigmast-5-en-3β,7α-diol (7), β-sitosterol (8), daucosterol (9), scopoletin (10), and hexacosanoic acid (11). Compounds 1-3 and 8-11 were isolated from the plant for the first time, and the abietane diterpene derivatives, compounds 1 and 2, were not reported previously from the genus Aglaia. Compound 1 showed weak activity against AGZY 83-a (human lung cancer) cell with the IC₅₀ value of 20.5 μg mL^-1. The study establishes a theoretical basis for the application of the genus Aglaia distributed in China.

Key words:Aglaia testicularis;Phlogacantholide B;Phlogacanthoside A;Cytotoxicity;Chemical constituents