Abstract:Five compounds were obtained from the EtOH extract of mangrove plant Scyphinphora hydrophyllacea Gaertn. f.. On the basis of spectral data (NMR, MS, etc.), they were identified as shanzhigenin methyl ester (1), 1-epishanzhigenin methyl ester (2), kaempferol (3), apigenin (4), and 5,7,2'-trihydroxy1-3,6,8,4',5'-pentamethoxyflavone (5). All the compounds were isolated from S. hydrophyllacea for the first time. The mixture of compounds 1 and 2 showed inhibitory activities towards human hepatoma (SMMC-7721) cell line.