Bioactive Constituents from Hydnocarpus hainanensis (Merr.) Sleum.

Abstract:

The ethanol extract from the stems of Hydnocarpus hainanensis (Merr.) Sleum. was separated and purified by means of chromatographic technology, and six compounds were isolated. On the basis of spectral data, they were identified as coniferaldehyde (1), mulberroside C (2), mulberrofuran G (3), mulberrofuran K (4), morusin (5) and daucosterol (6). All the compounds were isolated from H. hainanensis for the first time. Compound 1 showed inhibitory activities towards human hepatoma cell line (SMMC-7721) and human gastric carcinoma (SGC-7901) cell line, and compounds 3 and 5 showed obvious inhibitory activities towards SGC-7901.

Key words:Hydnocarpus hainanensis;Stem;Chemical constituent;Cytotoxicity