Cardenolides from the Seeds of Antiaris toxicaria and Their Cytotoxicity

Abstract:

Seven compounds were obtained from the EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. On the basis of spectral analysis (NMR, MS, IR, etc.), their structures were identified as: periplogenin (1), antialloside (2), antiogoside (3), strophanthidin (4), strophalloside (5), strophanthojavoside (6), and desglucocheirotoxin (7). Compound 7 was isolated from the seeds of Antiaris toxicaria for the first time. All of the compounds showed significant inhibitory activities towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines.

Key words:Antiaris toxicaria (Pers.) Lesch.; Seeds; Cardenolides; Cytotoxicity