Triterpenoid saponins from Lysimachia patungensis and their anti-tumor activities in vitro

Abstract:

Two triterpenoid saponins, characterized by the oleanane-derived sapogenol, were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz., and their structures were established as ardicrenin (1) and ardisiacrispin A (2) by spectral data. The TC₅₀s of ardicrenin (1) against cell lines SWO-38, KB , MCF-7 and Hela in vitro were 3.16, 3.16, 2.97, 2.42 μmol/L, respectively, and those of ardisiacrispin A (2) against the cell lines were 3.96, 3.01, 1.98, 2.73 μmol/L, respectively.