绵萆薢三萜皂苷类成分研究

Triterpenoid Saponins from the Rhizome of Dioscorea spongiosa

摘要:

为了解绵萆薢（Dioscorea spongiosa）的化学成分，从其70%乙醇水溶液提取物中分离鉴定了8个化合物，经理化性质和波谱数据分析分别鉴定为：20（S）-人参皂苷Rh₁（1）、人参皂苷Rg₁（2）、人参皂苷Re（3）、三七皂苷R₁（4）、人参皂苷Rd（5）、人参皂苷Rb₁（6）、常青藤皂苷元3-O-α-L-吡喃阿拉伯糖苷（7）和木通皂苷D（8）。化合物1、2、3、5和6为首次从该种植物中分离得到，化合物7和8为首次从薯蓣属植物中分离得到。

Abstract:

In order to understand the chemical constituents of Dioscorea spongiosa, eight triterpenoid saponins were obtained from 70% EtOH extract of its rhizome. On the basis of their physicochemical and spectral data, these saponins were identified as 20(S)-ginsenoside Rh₁ (1), ginsenoside Rg₁ (2), ginsenoside Re (3), notoginsenoside R₁ (4), ginsenoside Rd (5), ginsenoside Rb₁ (6), hederagenin-3-O-α-L-arabinopyranoside (7), and akebiasaponin D (8). Among them, compounds 1, 2, 3, 5 and 6 were isolated from this species for the first time, and compounds 7 and 8 were obtained from the genus Dioscorea for the first time.