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木槿的化学成分研究
程子洋1, 柯仲成1, 张愉快1, 赵奎奎1, 王国凯2
1.黄山学院化学化工学院, 安徽 黄山 245041;2.安徽中医药大学药学院, 合肥 230012
摘要:  为了解木槿(Hibiscus syriacus)茎的化学成分,采用MCI-gel中压柱层析、硅胶柱层析、Sephadex LH-20凝胶柱层析和高效液相色谱等色谱方法,从木槿茎85%乙醇提取物中分离得到13个化合物。根据理化性质和波谱数据,其结构分别鉴定为methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl) ethyl]sinapate (1)、2,6,2',6'-四甲氧基-4,4'-二(2,3-环氧-1-羟基丙基)二苯(2)、3,4,5-三甲氧基肉桂酸甲酯(3)、3,4-二甲氧基肉桂酸甲酯(4)、对羟基肉桂酸甲酯(5)、咖啡酸甲酯(6)、阿魏酸甲酯(7)、丁香脂素(8)、clemaphenol A (9)、(E)-3-hydroxyanethole β-d-glucopyranoside (10)、荭草苷(11)、木犀草素(12)和芹菜素(13)。其中化合物1~10为木脂素类,化合物11~13为黄酮类,化合物1为新天然产物,化合物1~12为首次从该植物中分离得到。采用MTS法检测,40μmol/L的化合物1~10对人白血病HL-60细胞和人肺癌A-549细胞株体外生长均未显示出较好的抑制活性。
关键词:  木槿  化学成分  木脂素  结构鉴定
DOI:10.11926/jtsb.4288
分类号:
基金项目:安徽省高校自然科学研究一般项目(KJHS2019B05);安徽省高校优秀青年人才支持计划重点项目(gxyqZD2019035);安徽省大学生创新创业项目(S201910375068)资助
Chemical Constituents from the Stems of Hibiscus syriacus
CHENG Zi-yang1, KE Zhong-cheng1, ZHANG Yu-kuai1, ZHAO Kui-kui1, WANG Guo-kai2
1.College of Chemistry and Chemical Engineering, Huangshan University, Huangshan 245041, Anhui, China;2.School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Abstract:  In order to understand the chemical constituents of Hibiscus syriacus stem, thirteen copounds were isolated from 85% ethanol extract of its stems by several column chromatographic techniques, such as MPLC- MCI-gel, silica gel, Sephadex LH-20 and preparative HPLC. Based on physicochemical properties and NMR spectral data, their structures were identified as methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl) ethyl] sinapate (1), 2,6,2ʹ,6ʹ-tetramethoxy-4,4ʹ-bis(2,3-epoxy-1-hydroxypropyl) biphenyl (2), 3,4,5- trimethoxycinnamic acid methyl ester (3), 3,4-dimethoxycinnamic acid methyl ester (4), trans-p-hydroxy- cinnamic acid methyl ester (5), methyl caffeate (6), methyl feruate (7), syringaresinol (8), clemaphenol A (9), (E)-2-methoxy-5-propenylphenyl β-d-glucopyranoside (10), orientin (11), luteolin (12), and apigenin (13). Among them, compounds 1-10 were lignans and compounds 11-13 were flavonoids. Compound 1 was a new natural product, compound 1-12 were isolated from this plant for the first time. Compounds 1-10 at 40 μmol/L did not exhibit good cytotoxic activities to in vitro growth of human leukemia HL-60 cells and human lung cancer A-549 cells.
Key words:  Hibiscus syriacus  Chemical constituents  Lignan  Structure identification

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