鹰爪花中生物碱类成分研究

Studies on the Alkaloids from Artabotrys hexapetalus

摘要:

为了解鹰爪花（Artabotrys hexapetalus）的化学成分，采用各种柱层析和色谱方法从鹰爪花茎中分离鉴定了12种生物碱类化合物，分别为：光千金藤定碱（1）、四氢非洲防己碱（2）、四氢药根碱（3）、前莲碱（4）、奥可梯木种碱（5）、华防己碱（6）、深山黄堇碱（7）、光千金藤碱（8）、鹰爪花碱（9）、lanuginolide（10）、isoscoulerine（11）和N-甲基阿西米洛宾（12）。其中化合物1~7均为首次从鹰爪花属植物中分离得到。化合物10对白色葡萄球菌（Staphylococcus albus）和蜡状芽孢杆菌（Bacillus cereus）生长都具有较好的抑制作用，MIC值分别为20和10 μg mL^-1。

Abstract:

In order to search the chemical constituents of Artabotrys hexapetalus, twelve alkaloid compounds were isolated from the stems of A. hexapetalus. On the basis of spectal data, they were identified as stepholidine (1), tetrahydrocolumbamine (2), tetrahydrojatrorrhizine (3), pronuciferine (4), glaziovina (5), sinoacutine (6), pallidine (7), stepharine (8), artacinatine (9), lanuginolide (10), isoscoulerine (11) and N-methylasimilobine (12). The alkaloids 1-7 were isolated from the genus Artabotrys for the first time. Compound 10 showed potent antibacterial effects on Staphylococcus albus and Bacillus cereus, with MIC of 20 and 10 μg mL^-1, respectively.