国产人工打洞沉香的化学成分研究

Chemical Constituents of Chinese Agarwood Induced by Artificial Holing

摘要:

为了解国产人工打洞方法所结沉香的化学成分,从国产人工打洞沉香的乙酸乙酯提取物中分离得到8个化合物,经波谱分析分别鉴定为：5-羟基-7,4'-二甲氧基黄酮 (1)、3-羟基-4-甲氧基-苯丙酸甲基酯 (2)、姜油酮 (3)、对甲氧基苯丙酸 (4)、正三十二烷醇 (5)、(20R)-24-ethylcholest-4-en-3-one (6)、麦角-4,6,8(14),22-四烯-3-酮 (7)、豆甾醇 (8)。化合物1, 2, 4~8均为首次从沉香中分离得到的化合物。抗菌活性表明化合物3对金黄色葡萄球菌(Staphylococcu aureus)和烟草青枯菌(Ralstonia solanacearum)均有抑制作用,化合物7仅对烟草青枯菌具有抑制作用。

Abstract:

In order to understand the chemical constituents of Chinese agarwood induced by artificial holing, eight compounds were isolated from its ethyl acetate extract. On the basis of spectral data, they were identified as 5-hydroxy-7,4'-dimethoxyflavone (1), benzenepropanoic acid, 3-hydroxy-4-methoxy-methyl ester (2), zingerone (3), p-methoxy phenylpropionic acid (4), n-dotriacontanol (5), (20R)-24-ethylcholest-4-en-3-one (6), ergosta- 4,6,8(14),22-tetraene-3-one (7), stigmasterol (8). Compounds 1, 2, and 4-8 were isolated from agarwood for the first time. Compound 3 had inhibitory activities against to Staphylococcus aureus and Ralstonia solanacearum, while compound 7 only to R. solanacearum.