赣南脐橙枝条内生真菌小新壳梭孢的化学成分研究

Chemical Constituents of the Endophytic Fungus Neofusicoccum parvum from Twig of Gannan Navel Orange

摘要:

为揭示赣南脐橙枝条内生真菌小新壳梭孢(Neofusicoccum parvum) QCZ-8的化学成分，利用多种色谱分离技术从其大米发酵物中分离鉴定了9个化合物。根据波谱数据，分别鉴定为5,7-二羟基-6-甲氧基-3-甲基异香豆素 (1)、(+)-orthosporin (2)、22Z-麦角甾-4,6,8(14),22-四烯-3-酮 (3)、豆甾-4-烯-3-酮 (4)、过氧化麦角甾醇 (5)、9,11-去氢过氧化麦角甾醇 (6)、7-羟基-2,5-二甲基-4H-1-苯并吡喃-4-酮 (7)、(S)-甲羟戊酸内酯 (8)和2,3-二羟基丙基乙酸酯 (9)，其中化合物1为新化合物，化合物5为首次从小新壳梭孢得到，其余7个化合物为首次从新梭壳孢属得到。

Abstract:

To clarify the chemical constituents of endophytic fungus Neofusicoccum parvum QCZ-8 isolated from twig of Gannan navel orange, nine compounds were obtained from the rice fermentation of this fungus by multiple chromatographic techniques. Based on spectral data, they were identified as 5,7-dihydroxy-6-methoxyl-3-methyl-isocoumarin (1), (+)-orthosporin (2), 22Z-ergosta-4,6,8(14),22-tetraen-3-one (3), stigmast-4-en-3-one (4), ergosterol peroxide (5), 9,11-dehydroergosterol peroxide (6), 7-hydroxy-2,5-dimethyl-4H-1-benzopyran-4-one (7), (S)-mevalonolactone (8), and 2,3-dihydroxypropyl acetate (9). Among them, compound 1 was a new compound, compound 5 was isolated from this fungus for the first time, and the remaining seven compounds were obtained from the genus Neofusicoccum for the first time.