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紫金龙根中异喹啉生物碱及其抗菌活性研究
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国家自然科学基金项目(32000274)；云南省基础研究项目(202101AU070069,202101AY070001-066)；云南省南药重点实验室开放基金(202105AG070012ZD2220)资助


Isoquinoline Alkaloids from the Roots of Dactylicapnos scandens and Their Antibacterial Activities
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    摘要:

    为了解紫金龙(Dactylicapnos scandens)中异喹啉生物碱化学成分及其抗菌活性，从紫金龙根的乙酸乙酯部位分离得到10个异喹啉类生物碱，根据理化性质和波谱数据，其结构分别鉴定为普罗托品 (1)、1-甲氧基小檗碱 (2)、别隐品碱 (3)、伪普鲁托品 (4)、巴马汀 (5)、青藤碱 (6)、药根碱 (7)、血根碱 (8)、四氢巴马汀 (9)、异紫堇定 (10)。化合物2~4、8为首次从该种植物中分离得到，其中化合物4对大肠杆菌表现出潜在的抑制活性，MIC值为6.25 μg/mL，抗菌活性优于临床抗菌药物小檗碱(25.0 μg/mL)。

    Abstract:

    To study the isoquinoline alkaloids of Dactylicapnos scandens and their antibacterial activities, ten isoquinoline alkaloids were isolated from its roots. Based on physical and chemical properties and spectral data, their structures were identified as protopine (1), 1-methoxyberberine (2), allocryptopine (3), pseudoprotopine (4), palmatine (5), sinomenine (6), jatrorrhizine (7), sanguinarine (8), tetrahydropalmatine (9), isocorydine (10). Compounds 2-4 and 8 were isolated from this plant for the first time. Moreover, compound 4 exhibited significant antimicrobial activity against Escherichia coli with an MIC value of 6.25 μg/mL, which is better than the clinical antibacterial drug berberine (25.0 μg/mL).

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高雯,吴昊,胡显光,于浩飞,张荣平,丁彩凤.紫金龙根中异喹啉生物碱及其抗菌活性研究[J].热带亚热带植物学报,2024,32(4):555~561

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  • 收稿日期:2023-04-10
  • 最后修改日期:2023-05-22
  • 在线发布日期: 2024-08-21
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