广藿香内生真菌Ogataea sp. RW-S10次级代谢产物研究

Study on Secondary Metabolites of Endophytic Fungus Ogataea sp. RW-S10 from the Pogostemon cablin

摘要:

为挖掘广藿香(Pogostemon cablin)内生真菌活性代谢产物，采用多种柱色谱分离方法从广藿香内生真菌Ogataea sp.RW-S10的次级代谢产物中分离得到7个化合物，根据波谱数据分别鉴定为ogataearin (1)、phenylalaninol (2)、对羟基苯乙酮(3)、bis(dethio)bis(methylsulfanyl) gliotoxin (4)、N-苯乙基乙酰胺(5)、lumichrome (6)和dehydroxypaxilline (7)，其中化合物1为新化合物。化合物1具有α-葡萄糖苷酶抑制活性，其IC₅₀值为39.38 μmol/L。

Abstract:

In order to obtain bioactive metabolites from Pogostemon cablin endophytic fungus, seven secondary metabolites were isolated and purified from the patchouli endophytic fungus Ogataea sp. RW-S10 by various chromatographic column techniques. Based on spectral data, their structures were identified as ogataearin (1), phenylalaninol (2), parahydroxyacet-ophenone (3), bis(dethio)bis(methylsulfanyl)gliotoxin (4), N-phenylethyl acetamide (5), lumichrome (6), and dehydroxypaxilline (7). Compound 1 was a new compound and showed α-glucosidase inhibitory activity with IC₅₀ value of 39.38 μmol/L.