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广藿香内生真菌Ogataea sp. RW-S10次级代谢产物研究
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海南省重点研发计划项目(ZDYF2021SHFZ075)；财政部和农业农村部国家现代农业产业技术体系专项(CARS-21)；农业农村部财政专项项目(NFZX2021)；中国热带农业科学院基本科研业务费专项(1630052022030)资助


Study on Secondary Metabolites of Endophytic Fungus Ogataea sp. RW-S10 from the Pogostemon cablin
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Key Research and Development Plan Projects of Hainan Province (Grant No. ZDYF2021SHFZ075), the Ministry of Finance and the Ministry of Agriculture and Rural Affairs of the National Modern Agricultural Industrial Technology System Special Project (Grant No. CARS-21), the Financial Special Project of the Ministry of Agriculture and Rural Affairs (Grant No. NFZX2021), and the Chinese Academy of Tropical Agricultural Sciences basic Scientific Research Business Expenses Special Project (Grant No. 1630052022030).

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    摘要:

    为挖掘广藿香(Pogostemon cablin)内生真菌活性代谢产物，采用多种柱色谱分离方法从广藿香内生真菌Ogataea sp.RW-S10的次级代谢产物中分离得到7个化合物，根据波谱数据分别鉴定为ogataearin (1)、phenylalaninol (2)、对羟基苯乙酮(3)、bis(dethio)bis(methylsulfanyl) gliotoxin (4)、N-苯乙基乙酰胺(5)、lumichrome (6)和dehydroxypaxilline (7)，其中化合物1为新化合物。化合物1具有α-葡萄糖苷酶抑制活性，其IC50值为39.38 μmol/L。

    Abstract:

    In order to obtain bioactive metabolites from Pogostemon cablin endophytic fungus, seven secondary metabolites were isolated and purified from the patchouli endophytic fungus Ogataea sp. RW-S10 by various chromatographic column techniques. Based on spectral data, their structures were identified as ogataearin (1), phenylalaninol (2), parahydroxyacet-ophenone (3), bis(dethio)bis(methylsulfanyl)gliotoxin (4), N-phenylethyl acetamide (5), lumichrome (6), and dehydroxypaxilline (7). Compound 1 was a new compound and showed α-glucosidase inhibitory activity with IC50 value of 39.38 μmol/L.

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阮武,郭教岑,马青云,杨理,谢晴宜,吴友根,赵友兴.广藿香内生真菌Ogataea sp. RW-S10次级代谢产物研究[J].热带亚热带植物学报,2023,31(5):741~746

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  • 收稿日期:2022-04-08
  • 最后修改日期:2022-07-01
  • 录用日期:2022-07-21
  • 在线发布日期: 2023-09-26
  • 出版日期: 2023-09-20
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