贵州鼠尾草化学成分研究

Chemical Constituents of Salvia cavaleriei

摘要:

为了解贵州鼠尾草(Salvia cavaleriei)的化学成分，运用色谱分离技术，从其95%乙醇提取物中分离得到16个化合物，经波谱数据分析分别鉴定为：β-倍半水芹烯 (1)、6R-(7R,11-二甲基-10-乙烯亚基)-环己烯酮 (2)、β-没药烯 (3)、α-姜黄烯 (4)、3,4-二羟基苯乙酸甲酯 (5)、香草醛 (6)、姜油酮 (7)、6-姜烯酚 (8)、阿魏酸十八烷酯 (9)、维生素E醌 (10)、5-羟甲基-2-糠醛 (11)、硫代乙酸酐 (12)、吲唑 (13)、棕榈酸 (14)、角鲨烯 (15)和二十六烷 (16)。其中，化合物2为新天然产物，除化合物3、4和6外，所有化合物均为首次从贵州鼠尾草中分离得到，此外，化合物2、5、9和12为首次从唇形科(Lamiaceae)植物中分离得到，化合物1和15为首次从鼠尾草属植物中分离得到。

Abstract:

The aim was to clarify the chemical constituents of Salvia cavaleriei. Sixteen compounds were isolated from the 95% ethanol extract by using chromatographic separation techniques, such as silica gel, LH-20, MCI, and HPLC methods. On the basis of spectral data, their structures were identified as β-sesquiphellandrene (1), 6R-(7R,11-dimethyl-10-ethenylene)-cyclohexenone (2), β-bisabolene (3), α-curcumene (4), 3,4-dihydroxy- phenylacetic acid methyl ester (5), vanillin (6), zingerone (7), 6-shogaol (8), octadecyl ferulate (9), vitamin E quinone (10), 5-hydroxymethyl-2-furaldehyde (11), thioacetic anhydride (12), 3,4-dihydroxyphenylacetic indazole (13), hexadecanoic acid (14), squalene (15), and hexacosane (16). Among them, compound 2 is a new natural compound. Moreover, all compounds were obtained from this plant species for the first time except for compounds 3, 4 and 6. Accordingly, compounds 2, 5, 9 and 12 were isolated for the first time from Labiatae, compounds 1 and 15 were obtained from Salvia genus for the first time.