姜状三七根茎的皂苷类化学成分研究

Saponins from Rhizomes of Panax zingiberensis

摘要:

为了解姜状三七(Panax zingiberensis)根茎的皂苷类化学成分，采用正相硅胶、反相硅胶和凝胶等色谱方法从其根茎的乙醇提取物中得到9个皂苷类化合物，根据理化性质和波谱数据，其结构分别鉴定为人参皂苷SL₁ (1)、人参皂苷Rh₁ (2)、三七皂苷R₈ (3)、竹节参皂苷IVa (4)、越南人参皂苷R₁₀ (5)、人参皂苷Rg₁ (6)、菠菜皂苷A 28-O-β-d-葡萄糖苷 (7)、齐墩果酸28-O-β-d-葡萄糖苷 (8)和姜状三七苷R₁ (9)。化合物1、3、5、7和8为首次从该植物中分离得到, 其中化合物5为奥克梯隆醇型皂苷，此类皂苷在该植物中未见报道。

Abstract:

To investigate the chemical constituents from rhizomes of Panax zingiberensis, nine compounds were isolated and purified by methods of column chromatography on silica gel and Sephadex LH-20. Based on physical and chemical properties and spectral data,their structures were identified as ginsenoside SL₁ (1), ginsenoside Rh₁ (2), notoginsenoside R₈ (3), chikusetsusaponin IVa (4), vina-ginsenoside 10 (5), ginsenoside Rg₁ (6), spinasaponin A 28-O-β-d-glucopyranoside (7), oleanolic acid 28-O-β-d-glucopyranoside (8) and zingbroside R₁ (9). Compounds 1, 3, 5, 7, and 8 were isolated from P. zingiberensis for the first time. Compound 5 belongs to the ocotillol-type saponin, which was not previously reported from this species.