Abstract:WOX (WUSCHEL-related homeobox) transcription factors (TFs) are closely associated with plant development, including embryogenesis, somatic embryogenesis, flower and root development, the initiation and maintenance of callus, and stem cell maintenance in plants. Increasing studies demonstrated that WOX TFs play a crucial role in plant development. Studied on the regulatory mechanisms of WOX in plant development provide a breakthrough in promoting plant development and constructing excellent plant phenotypes. The regulation of WOX TFs in plant development was reviewed, and the developmental processes by integrating WOX and epigenetic regulation were discussed, which aimed at providing inspiration for the mechanism of WOX TFs in regulating plant development.