毛山小橘枝叶中生物碱类成分的研究

Studies on the Alkaloids from Twigs and Leaves of Glycosmis craibii

摘要:

为了解毛山小橘(Glycosmis craibii)的化学成分，采用硅胶柱层析、ODS柱层析、Sephadex LH-20凝胶柱层析和高效液相色谱等现代色谱分离技术，从毛山小橘枝叶95%乙醇提取物中分离得到9个生物碱类化合物。根据化合物的理化性质和波谱数据，其结构分别鉴定为de-N-methyl-O-noracronycine (1)、去甲山油柑碱(2)、glycocitrine Ⅱ (3)、acrifoline (4)、3-hydroxy- 2, 4-dimethoxy-10-methyl-9-acridanone (5)、阿塔宁(6)、glycosolone (7)、3-(3?, 3?-dimethylallyl)-4, 8-dimethoxy-N-methyl-quinolin- 2-one (8)和4-methoxy-N-methyl-2-quinolone (9)。所有化合物均为首次从该植物中分离，其中化合物2、3、5、6和9为首次从山小橘属植物中分离得到。

Abstract:

In order to clarify the alkaloids in the twigs and leaves of Glycosmis craibii, nine alkaloids were isolated from 95% ethanol extract of G. craibii by several column chromatographic techniques, such as MPLC, MCI-gel, silica gel, Sephadex LH-20 and preparative HPLC. Based on physicochemical properties and NMR spectral data, their structures were identified as de-N-methyl-O-noracronycine (1), noracronycine (2), glycocitrine Ⅱ (3), acrifoline (4), 3-hydroxy-2, 4-dimethoxy-10-methyl-9-acridanone (5), atanine (6), glycosolone (7), 3-(3?, 3?- dimethylallyl)-4, 8-dimethoxy-N-methyl-quinolin-2-one (8) and 4-methoxy-N-methyl-2-quinolone (9). It is the first report of all the alkaloids isolated from this species and compunds2,3,5,6 and9 from the genus Glycosmis.