何首乌化学成分及其药理活性的研究进展

Advances in Chemical Constituents and Pharmacological Activities of Pleuropterus multiflorus

摘要:

何首乌（Pleuropterus multiflorus）是一种珍贵的多年生中药，为蓼科（Polygonaceae）何首乌属植物，主要分布在四川、云南、贵州以及山西和甘肃南部，可用于治疗肝损伤、癌症、糖尿病、脱发、动脉粥样硬化以及神经退行性疾病。近年来，国际上有报道称摄入何首乌会引起肝损伤，因此，建立何首乌的安全监测和风险管理模型对何首乌的开发利用具有重要意义。对何首乌的化学成分、药理活性及其毒副作用进行了综述，为何首乌的临床应用、科学研究和生产质量控制提供参考。

Abstract:

Pleuropterus multiflorum, known as one of precious perennial Chinese traditional medicine, belonging to Pleuropterus genus and Polygonaceae family, distributed mainly in Sichuan, Yunnan, Guizhou and southern Shanxi and Gansu in China. The modern studies showed that P. multiflorum could be used for liver injury, cancer, diabetes, alopecia, atherosclerosis, and neurodegenerative diseases as well. In recent years, liver injuries caused by taking P. multiflorum have been reported worldwide. Therefore, the model of safety monitoring and risk management of P. multiflorum is very important. The chemical constituents and medicinal activities of P. multiflorum, including the toxic effects were summarized for the further studies and development, which is beneficial for the strengthening standardization of clinical applications, basic science research, quality control in manufacturing.