LC-MS导向分离山壳骨中主成分及其生物活性研究

LC-MS Guided Isolation of Chemical Constituents from Pseuderanthemum latifolium and Their Biological Activities

摘要:

为了解山壳骨（Pseuderanthemum latifolium）的化学成分和生物活性，运用LC-MS联用技术分离得到羽扇豆醇（1）和豆甾醇（2）。体外活性评价结果表明，化合物1和2均具有中等的抗MRSA活性，但不具有神经保护作用。这是首次对山壳骨进行化学成分和生物活性研究，为综合开发与利用山壳骨提供科学依据。

Abstract:

In order to study the chemical constituents from Pseuderanthemum latifolium and their biological activities, two main compounds were isolated from the EaOAc fraction and identified as lupeol (1) and stigmasterol (2) by using LC-MS guided isolation. In vitro activity screening, all these compounds showed moderate anti-MRSA activities but no neuroprotective effects. This is the first report about the chemical constituents from P. latifolium and their biological activities, which would provide scientific basis to the development and utilization of P. latifolium.