大叶桃花心木根的化学成分研究

Chemical Constituents from the Roots of Swietenia macrophylla King

摘要:

为了解大叶桃花心木（Swietenia macrophylla King）的化学成分，从其根的乙醇提取物中共分离得到13个化合物，经理化性质和波谱分析，分别鉴定为1，5-dihydroxyxanthone （1）、1，6-dihydroxy-5-methoxyxanthone （2）、euxanthone （3）、1，2-dimeth-oxyxanthone （4）、（+）儿茶素（5）、（+） sesamin （6）、bis-（2-ethylhexyl） phthalate （7）、3-oxotirucalla-7，24-dien-21-oic acid （8）、（20S）-3β-acetoxy-24-methylenedam-maran-20-ol （9）、cycloeucalenol （10）、β-谷甾醇（11）、7-deacetoxy-7-oxogedunin （12）和7-deacetoxy-7α-hydroxygedunin （13），其中化合物1~4、6~10和13为首次从桃花心木属植物中分离得到，且化合物4对乙酰胆碱酯酶具有一定的抑制活性。

关键词:大叶桃花心木;化学成分;(口山)酮;柠檬苦素;乙酰胆碱酯酶抑制活性

Abstract:

In order to understand the chemical constituents of Swietenia macrophylla King, thirteen compounds were isolated from its roots. On the basis of spectral data, they were identified as 1,5-dihydroxyxanthone (1), 1,6-dihydroxy-5-methoxyxanthone (2), euxanthone (3), 1,2-dimethoxyxanthone (4), (+) catechin (5), (+) sesamin (6), bis-(2-ethylhexyl) phthalate (7), 3-oxotirucalla-7,24-dien-21-oic acid (8), (20S)-3β-acetoxy-24-methylenedam-maran-20-ol (9), cycloeucalenol (10), β-sitosterol (11), 7-deacetoxy-7-oxogedunin (12) and 7-deacetoxy-7α-hydroxygedunin (13). Among them, compounds 1-4, 6-10 and 13 were isolated from the genus Swietenia for the first time. Moreover, compound 4exhibited inhibitory activity against acetylcholinesterase.

Key words:Swietenia macrophylla;Chemical constituent;Xanthone;Limonoid;Anti-acetylcholinesterase activity