海南栽培肾茶的化学成分研究

Chemical Constituents from the Cultivated Clerodendranthus spicatus (Thunb.) C. Y. Wu in Hainan

摘要:

为了解肾茶（Clerodendranthus spicatus）的化学成分，从海南栽培肾茶地上部分分离得到11个化合物，经波谱分析分别鉴定为：吐叶醇（1）、丁香脂素（2）、3，4-二羟基苯乙醇（3）、甜橙素（4）、5，6，7，4'-四甲氧基黄酮（5）、5-羟基-6，7，3'，4'-四甲氧基黄酮（6）、6-羟基-5，7，4'-三甲氧基黄酮（7）、5-羟基-6，7，3'，4'-四甲氧基黄烷酮（8）、3，3'，5-三羟基-4'，7-二甲氧基-二氢黄酮（9）、松脂素（10）和熊果酸（11）。化合物3、9和10为首次从肾茶中分离得到。对化合物1~6进行活性测试，结果表明化合物3~5对乙酰胆碱酯酶具有一定的抑制活性。

Abstract:

In order to understand the chemical constituents of Clerodendranthus spicatus (Thunb.) C. Y. Wu, eleven compounds were isolated from its aerial part cultivated in Hainan. On the basis of spectral data, their structures were identified as: vomifoliol (1), (-)-syringaresinol (2), 3,4-dihydroxyphenylethl alcohol (3), sinesetin (4), 5,6,7,4'-tetramethoxyflavone (5), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (6), 6-hydroxy-5,7,4'-trimethoxyflavone (7), 5-hydroxy-6,7,3',4'-tetramethoxyflavanone (8), 3,3',5-trihydroxy-4',7-dimethoxyflavanone (9), pinoresinol (10) and ursolic acid (11). Compounds 3, 9 and 10 were obtained from this species for the first time. The compounds 3-5 exhibited inhibitory activity against acetylcholinesterase.