火绒草的苯丙素类成分

Phenylpropanoids from Lentopodium lenotopodioides

摘要:

采用含水乙醇提取、三氯甲烷脱色、正丁醇萃取和多种色谱分离方法，从新疆产菊科植物火绒草（Lentopodium lenotopodioides）全草中获得8个苯丙素类化合物。通过波谱数据分析，分别鉴定为二氢去氢二松柏醇4-O-β-d-葡萄糖苷（1）、二氢去氢二松柏醇9'-O-β-d-葡萄糖苷（2）、去氢二松柏醇9'-O-β-d-葡萄糖苷（3）、去氢二松柏醇9'-甲醚-4-O-β-d-葡萄糖苷（4）、（-）-松脂醇4-O-β-d-葡萄糖苷（5）、（-）-杜仲树脂酚4-O-β-d-葡萄糖苷（6）、枸橼苦素C（7）和咖啡酸（8）。化合物2~7为首次从该植物中报道。在500 μmol L^-1浓度下，这些化合物对α-葡萄糖苷酶的抑制率均低于50%。

Abstract:

In order to understand the chemical constituents from Lentopodium lenotopodioides (Asteraceae), eight phenylpropanoids were obtained from its whole herbs by multiple chromatographic separation techniques. On the basis of spectral data, their structures were identified as dihydrodehydrodiconiferyl alcohol 4-O-β-d-glucoside (1), dihydrodehydrodiconiferyl alcohol 9'-O-β-d-glucoside (2), dehydrodiconiferyl alcohol 9'-O-β-d-glucoside (3), dehydrodiconiferyl alcohol 9'-methyl ether-4-O-β-d-glucoside (4), (-)-pinoresinol 4-O-β-d-glucoside (5), (-)-medioresinol 4-O-β-d-glucoside (6), citrusin C (7), and caffeic acid (8). Compounds 2-7 were obtained from this species for the first time. The inhibitory rates of these compounds toward α-glucosidase were less than 50% at the concentration of 500 μmol L^-1.