毛果鱼藤化学成分及生物活性研究

Chemical Costituents and Bioactivities from Derris eriocarpa How

摘要:

为了解毛果鱼藤（Derris eriocarpa How）藤茎和根中的生物活性成分，采用柱色谱技术，从其乙酸乙酯萃取部位分离得到6个化合物，分别鉴定为：高丽槐素（1）、美迪紫檀素（2）、大黄素（3）、松脂醇（4）、（6R，9R）9-hydroxy-4-megastigmen-3-one（5）、2-methoxygliricidol（6）。这些化合物均为首次从该植物中分离得到。体外抑菌、细胞毒抑制活性测试结果表明，化合物1、2对部分肿瘤细胞株及结核分枝杆菌（H₃₇Rv）有明显抑制活性。

Abstract:

In order to understand the bioactivity constituents form Derris eriocarpa How, six compounds were isolated from ethyl acetate fraction of ethanol extract of its stems and roots by using chromatographic techniques. On the basis of spectral data, their structures were identified as (-)-maackiain (1), medicarpin (2), emodin (3), (-)-pinoresinol (4), (6R,9R)9-hydroxy-4-megastigmen-3-one (5), 2-methoxygliricidol (6). All these compounds were isolated from this species for the first time. Furthermore, compounds 1 and 2 exhibited significantly inhibitory activities in vitro against some of tumor cell lines and mycobacterium tuberculosis (H₃₇Rv).