麻楝枝干的化学成分及其α-葡萄糖苷酶抑制活性研究
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作者单位:

1.大理大学,药学与化学学院

基金项目:

公益性行业(农业)科研专项(201303117);海南省中药现代化专项(ZY201408);中国热带农业科学院热带生物技术研究所基本科研业务费(ITBB2015RC03)资助


Studies on the Chemical Constituents from the Stems of Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity
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Affiliation:

1. Dali University, College of Pharmacy and Chemistry

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    摘要:

    为了解麻楝(Chukrasia tabularis A. Juss)中的生物活性成分,采用柱色谱技术从其枝干乙醇提取物中分离得到10个化合物,分别鉴定为:3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (1)、6-hydroxy-1,3,5,7-tetramethoxy-9-xanthen-9-one(2)、2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl)biphenyl (3)、cleomiscosin D (4)、chuktabularin A (5)、chuktabularin B (6)、chubularisin H (7)、chubularisin I (8)、tabularisin A (9)和tabularisin B (10),其中化合物1~4为首次从麻楝属中分离得到。对体外α-葡萄糖苷酶的抑制活性进行了测定,结果表明化合物12679对α-葡萄糖苷酶均具有较好的抑制活性。

    Abstract:

    In order to find the bioactive components from the stems of Chukrasia tabularis, ten compounds were isolated from its EtOH extract by using chromatographic techniques. On the basis of spectral data, their structures were identified as 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (1), 6-hydroxy-1,3,5,7-tetrameth-oxy-9H-xanthen-9-one (2), 2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl) biphenyl (3), cleomiscosin D (4), chuktabularin A (5), chuktabularin B (6), chubularisin H (7), chubularisin I (8), tabularisin A (9), and tabularisin B (10). Compounds 1-4 were isolated from the genus Chukrasia for the first time. Furthermore, compounds 1, 2, 6, 7 and 9 exhibited inhibitory activity against α-glucosidase in vitro.

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彭俊霖,梅文莉,刘子琦,王佩,左文健,蔡彩虹,姜北,戴好富.麻楝枝干的化学成分及其α-葡萄糖苷酶抑制活性研究[J].热带亚热带植物学报,2016,24(1):99~105

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  • 收稿日期:2015-05-29
  • 最后修改日期:2015-07-13
  • 录用日期:2015-09-06
  • 在线发布日期: 2016-01-21
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