麻楝枝干的化学成分及其α-葡萄糖苷酶抑制活性研究

Studies on the Chemical Constituents from the Stems of Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity

摘要:

为了解麻楝(Chukrasia tabularis A. Juss)中的生物活性成分,采用柱色谱技术从其枝干乙醇提取物中分离得到10个化合物,分别鉴定为:3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (1)、6-hydroxy-1,3,5,7-tetramethoxy-9-xanthen-9-one(2)、2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl)biphenyl (3)、cleomiscosin D (4)、chuktabularin A (5)、chuktabularin B (6)、chubularisin H (7)、chubularisin I (8)、tabularisin A (9)和tabularisin B (10),其中化合物1~4为首次从麻楝属中分离得到。对体外α-葡萄糖苷酶的抑制活性进行了测定,结果表明化合物1、2、6、7和9对α-葡萄糖苷酶均具有较好的抑制活性。

Abstract:

In order to find the bioactive components from the stems of Chukrasia tabularis, ten compounds were isolated from its EtOH extract by using chromatographic techniques. On the basis of spectral data, their structures were identified as 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (1), 6-hydroxy-1,3,5,7-tetrameth-oxy-9H-xanthen-9-one (2), 2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl) biphenyl (3), cleomiscosin D (4), chuktabularin A (5), chuktabularin B (6), chubularisin H (7), chubularisin I (8), tabularisin A (9), and tabularisin B (10). Compounds 1-4 were isolated from the genus Chukrasia for the first time. Furthermore, compounds 1, 2, 6, 7 and 9 exhibited inhibitory activity against α-glucosidase in vitro.