北葶苈子黄酮苷类成分研究Ⅱ

Flavonoid Glycosides from Seeds of Lepidium apetalum Willd. (Ⅱ)

摘要:

为了解北葶苈子的化学成分,从其50%乙醇提取物中分离鉴定了8个单体成分,经理化性质和波谱数据分析,分别鉴定为:槲皮素-3-O-β-D-吡喃葡萄糖苷(1)、槲皮素-3-O-β-D-葡萄糖醛酸苷(2)、槲皮素-3,7-二-O-β-D-葡萄糖苷(3)、槲皮素-3-O-β-D-葡萄糖-(1→2)-β-D-葡萄糖苷(4)、quercetin-3-O-[2-O-(6-O-E-sinapoyl)-β-D-glucopyranosyl]-β-D-glucopyranoside (5)、槲皮素-3-O-[(6-O-trans-咖啡酰基)-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃葡萄糖]-7-O-β-D-吡喃葡萄糖苷 (6)、isorhamnetin-3-O-sophoroside (7)和异鼠李素-3-O-β-D-[2-O-(6-O-芥子酰基)-β-D-吡喃葡萄糖基]-吡喃葡萄糖苷(8)。化合物3为首次从该种中分离得到,化合物2、4、6、7为首次从独行菜属中分离得到,且化合物6的NMR 数据为首次报道。

Abstract:

In order to understand the chemical constituents of Lepidium apetalum Willd., eight flavonoid glycosides were obtained from 50% EtOH extract of its seeds. On the basis of physicochemical and spectral data, they were identified as quercetin-3-O-β-d-glucoside (1), quercetin-3-O-β-d-glucuronide (2), quercetin-3,7-di-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-glucosyl(1→2)-β-d-glucoside (4), quercetin-3-O-[2-O-(6-O-E-sinapoyl)-β-d-glucopyranosyl]-β-d-glucopyranoside (5), quercetin-3-O-[(6-O-trans-caffeoyl)-β-dglucopyranosyl(1→2)-β-d-glucopyranosyl]-7-O-β-d-glucopyranoside (6), isorhamnetin-3-O-sophoroside (7) and isorhamnetin-3-O-[2-O-(6-O-E-sinapoyl)-β-d-glucopyranosyl]-β-d-glucopyranoside (8). Among them, compound 3 was isolated from this species for the first time, and compounds 2, 4, 6 and 7 were obtained from Lepidium genus for the first time. Meanwhile, the NMR data of compound 6 was reported firstly.