海南石斛化学成分研究

Chemical Constituents from Dendrobium hainanense (Orchidaceae) in Hainan

摘要:

为了解海南石斛(Dendrobium hainanense Rolfe)的化学成分,采用色谱技术从海南石斛茎叶中分离得到14 个化合物,经波谱分析分别鉴定为:2,6-二甲氧基对苯醌 (1)、(+)-dehydrovomifoliol (2)、blumenol A (3)、2,7-二羟基-3,4-二甲氧基-9,10-二氢菲 (4)、2,7-二羟基-3,4-二甲氧基菲 (5)、3,7-二羟基-2,4-二甲氧基菲 (6)、3-羟基-2,4,7-三甲氧基-9,10-二氢菲 (7)、3-羟基-2,4,7-三甲氧基菲 (8)、3,4,7-三羟基-2-甲氧基菲 (9)、3,7-二羟基-2,4-二甲氧基-9,10-二氢菲 (10)、(+)-lyoniresinol (11)、丁香脂素 (12)、denchrysan A (13)和nobilone (14).这些化合物均为首次从海南石斛中分离得到.活性测试结果表明化合物4~6、8~9、11 和14 对乙酰胆碱酯酶有抑制活性.

Abstract:

The aim was to understand the chemical constituents of Dendrobium hainanense. Fourteen compounds were isolated from its aerial parts by means of chromatographic techniques. On the basis of spectral data, they were identified as: 2,6-dimethoxy-p-benzoquinone (1), (+)-dehydrovomifoliol (2), blumenol A (3), erianthridin (4), nudol (5), 3,7-dihydroxy-2,4-dimethoxy-phenanthrene (6),3-hydroxy-2,4,7-trimethoxy-9,10-dihydrophenanthrene (7), 3-hydroxy-2,4,7-trimethoxy-9,10-dihydro-phenanthrene (8), 3,4,7-trihydroxy-2-methoxyphenanthrene (9), 3,7-dihydroxy-2,4-dimethoxy-9,10-dihydro-phenanthrene (10), (+)-lyoniresinol (11), (+)- syringaresinol (12), denchrysan A (13) and nobilone (14). All compounds were isolated from D. hainenense for the first time. Compounds 4-6, 8-9, 11 and 14 showed weak inhibitory activity against acetylcholinesterase.