牛膝根化学成分研究

Chemical Constituents from Roots of Achyranthes bidentata

摘要:

为了解中药材牛膝(Achyranthes bidentata Blume)根中的有效成分,用色谱技术从牛膝根中分离得到12个化合物。经波谱分析分别鉴定为:水龙骨甾酮B (1),shidasterone (2),齐墩果酸(3),齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸-6′-O-甲酯 (4),竹节参苷Ⅳa甲酯 (5),N-顺式阿魏酰基酪胺(6),N-顺式阿魏酰-3-甲氧基酪胺(7),N-反式阿魏酰基酪胺(8),N-反式阿魏酰-3-甲氧基酪胺(9),(9E)-8,11,12-三羟基-十八碳烯酸(10),(9E)-8,11,12-三羟基-十八碳烯酸甲酯(11)和亚油酸(12)。其中化合物2、6、7和10～12为首次从牛膝中分离得到。这有利于对牛膝根进行更好地开发利用。

Abstract:

Twelve compounds were isolated from the roots of Achyranthes bidentata Blume. On the basis of spectral data, they were identified as polypodine B (1), shidasterone (2), oleanolic acid (3), oleanolic acid 3-O-β-D-glucuronopyranoside-6′-O-methyl ester (4), chikusetsusaponin Ⅵa methyl ester (5), N-cis-feruloyltyramine (6), N-cis-feruloyl-3-methoxytyramine (7), N-trans-feruloyltyramine (8), N-trans-feruloyl-3-methoxytyramine (9), tianshic acid (10), (9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester (11) and linoleic acid (12). Compounds 2, 6, 7, and 10-12 were obtained from the plant for the first time.