首页 > 过刊浏览>2013年第21卷第1期 >57-62. DOI:10.3969/j.issn.1005–3395.2013.01.008
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牛膝根化学成分研究
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作者单位:

湖南中医药大学药学院,湖南中医药大学药学院,中国科学院华南植物园 中国科学院植物资源保护与可持续利用重点实验室,中国科学院华南植物园 中国科学院植物资源保护与可持续利用重点实验室

基金项目:

国家自然科学基金项目(30870248);中国科学院知识创新工程重要方向项目(KSCX2-YW-N-0804)资助


Chemical Constituents from Roots of Achyranthes bidentata
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Affiliation:

School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou,Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou

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    摘要:

    为了解中药材牛膝(Achyranthes bidentata Blume)根中的有效成分,用色谱技术从牛膝根中分离得到12个化合物。经波谱分析分别鉴定为:水龙骨甾酮B (1),shidasterone (2),齐墩果酸(3),齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸-6′-O-甲酯 (4),竹节参苷Ⅳa甲酯 (5),N-顺式阿魏酰基酪胺(6),N-顺式阿魏酰-3-甲氧基酪胺(7),N-反式阿魏酰基酪胺(8),N-反式阿魏酰-3-甲氧基酪胺(9),(9E)-8,11,12-三羟基-十八碳烯酸(10),(9E)-8,11,12-三羟基-十八碳烯酸甲酯(11)和亚油酸(12)。其中化合物2、6、7和10～12为首次从牛膝中分离得到。这有利于对牛膝根进行更好地开发利用。

    Abstract:

    Twelve compounds were isolated from the roots of Achyranthes bidentata Blume. On the basis of spectral data, they were identified as polypodine B (1), shidasterone (2), oleanolic acid (3), oleanolic acid 3-O-β-D-glucuronopyranoside-6′-O-methyl ester (4), chikusetsusaponin Ⅵa methyl ester (5), N-cis-feruloyltyramine (6), N-cis-feruloyl-3-methoxytyramine (7), N-trans-feruloyltyramine (8), N-trans-feruloyl-3-methoxytyramine (9), tianshic acid (10), (9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester (11) and linoleic acid (12). Compounds 2, 6, 7, and 10-12 were obtained from the plant for the first time.

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引用本文

唐鑫,裴刚,周忠玉,谭建文.牛膝根化学成分研究[J].热带亚热带植物学报,2013,21(1):57~62

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  • 收稿日期:2012-05-15
  • 最后修改日期:2012-07-12
  • 录用日期:2012-09-12
  • 在线发布日期: 2013-01-17
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