马肾果枝条的化学成分研究

Chemical Constituents from Twigs of Aglaia testicularis C. Y. Wu

摘要:

采用多种色谱方法从马肾果(Aglaia testicularis C. Y. Wu)枝条中分离鉴定了11个化合物,分别是火焰花内酯B (1)、火焰花内酯苷A (2)、(E)-aglawone (3)、eichlerianic acid (4)、shoreic acid (5)、3β-羟基-5α,8α-表-二氧麦角-6,22-二烯(6)、豆甾-5-烯-3β,7α-二醇(7)、β-谷甾醇(8)、胡萝卜苷(9)、东莨菪内酯(10)、碳二十六酸(11)。化合物1～3, 8～11均为首次从该植物中分离得到,而松香烷二萜内酯类衍生物1和2则是首次从米仔兰属植物中得到。化合物1对人肺癌细胞株AGZY 83-a表现出弱的抑制作用,IC₅₀值为20.5 μg mL^-1。这为国产米仔兰属植物的开发应用提供了理论依据。

Abstract:

Eleven compounds were isolated from the twigs of Aglaia testicularis C. Y. Wu (Meliaceae) by means of chromatographic technology. On the basis of spectral data, their structures were identified as phlogacantholide B (1), phlogacanthoside A (2), (E)-aglawone (3), eichlerianic acid (4), shoreic acid (5), 3β-hydroxy-5α,8α-epidioxyergosta-6,22-diene (6), stigmast-5-en-3β,7α-diol (7), β-sitosterol (8), daucosterol (9), scopoletin (10), and hexacosanoic acid (11). Compounds 1-3 and 8-11 were isolated from the plant for the first time, and the abietane diterpene derivatives, compounds 1 and 2, were not reported previously from the genus Aglaia. Compound 1 showed weak activity against AGZY 83-a (human lung cancer) cell with the IC₅₀ value of 20.5 μg mL^-1. The study establishes a theoretical basis for the application of the genus Aglaia distributed in China.