小叶米仔兰枝条中的抗菌活性成分研究

Antibacterial Components from the Twigs of Aglaia odorata var. microphyllina

摘要:

为探讨小叶米仔兰(Aglaia odorata var. microphyllina)中的抗菌活性成分,从其枝条的乙醇提取物中分离得到6个化合物,通过波谱分析,分别鉴定为:4(15)-桉叶烯-1β,7,11-三醇 (1)、4α,10β,11-三羟基-1,5-反-愈创木烷-6-烯(2)、6,15α-环氧-1β,4β-二羟基桉烷(3)、2-羟基-丁二酸-1-甲酯(4)、巴西红厚壳素(5)和胡萝卜苷(6)。以上化合物均为首次从该植物中分离得到,其中化合物1、2、4和5为首次从米仔兰属植物中分离得到。用滤纸片琼脂扩散法测定了化合物1～5的抗菌活性,结果显示化合物4和5对金黄色葡萄球菌有抑制作用。

Abstract:

With the purpose of exploring antibacterial constituents of Aglaia odorata var. microphyllina, six compounds were isolated from the EtOH extract of the twigs. Their structures were identified as 4(15)-eudesmen- 1β,7,11-triol (1), 4α,10β,11-trihydroxy-1,5-trans-guai-6-ene (2), 6,15α-epoxy-1β,4β-dihydroxyeudesmane (3), 2-hydroxy-butandioic acid 1-methylester (4), jacarreubin (5) and daucosterol (6) on the basis of spectroscopic evidence. All the compounds above were isolated from this plant for the first time, and compounds 1, 2, 4, 5 were isolated from the plants of the genus Aglaia for the first time. Compounds 1-5 were tested antibacterial activity by the filter paper disc diffusion method, the result showed compounds 4 and 5 possessed inhibitory effects on Staphylococcus aureus.