酒饼簕根中的细胞毒活性成分

Cytotoxic Components from the Roots of Atalantia buxifolia (Poir.) Oliv.

摘要:

用色谱技术从酒饼簕[Atalantia buxifolia (Poir.) Oliv.]根的乙醇提取物中分离得到9 个化合物,经波谱分析与文献数据对照,分别鉴定为buxifoliadine A (1)、1,3-dihydroxy-2,4-diprenylacridone (2)、5-hydroxy-N-methylseverifoline (3)、buxifoliadine B (4)、N-methylatalaphylline (5)、atalaphylline (6)、东风桔碱(7)、葡萄内酯(8) 和松柏醛(9)。化合物9 为首次从酒饼簕根中分离得到。细胞毒活性测试结果表明,化合物1 和8 对人肝癌细胞(SMMC-7721)具有细胞毒活性,化合物3 对慢性髓原白血病细胞(K562)的增殖显示了较强的生长抑制活性。

Abstract:

Nine compounds were isolated from the ethanolic extract of roots of Atalantia buxifolia (Poir.) Oliv. by means of chromatographic technology. On the basis of spectral data, their structures were identified as buxifoliadine A (1), 1,3-dihy-droxy-2,4-diprenylacridone (2), 5-hydroxy-N-methylseverifoline (3), buxifoliadine B (4), N-methylatalaphylline (5), atalaphylline (6), atalafoline (7), aurapten (8), and coniferyl aldehyde (9). Compound 9 was isolated from the roots of A. buxifolia for the first time. Compounds 1 and 8 showed cytotoxic activities towards human hepatoma (SMMC-7721), and compound 3 showed significant inhibitory activity towards chronic myelogenous leukemia (K562).