海南产木薯茎化学成分研究

Chemical Constituents from the Stems of Cassava (Manihot esculenta) in Hainan

摘要:

从木薯(Manihot esculenta Crantz)茎的乙醇提取物中分离得到6个化合物,通过波谱分析,分别鉴定为呋喃(1)、肥牛木素(2)、3-吲哚甲酸(3)、3,9,13-megastigmanetriol (4)、穗花杉双黄酮(5)、yucalexin P-21 (6),其中化合物1~5为首次从该植物中分离得到。用滤纸片琼脂扩散法测定了这些化合物的抗菌活性,结果表明化合物1、3、4和6对耐甲氧西林金黄色葡萄球菌(MRSA)和金黄色葡萄球菌均有抑制作用。

Abstract:

Six compounds were isolated from the EtOH extract of Manihot esculenta (cassava) stems. On the basis of spectral data, they were identified as furan (1), ceplignan (2), indole-3-carboxylic acid (3), 3,9,13-megastigmanetriol (4), amentoflavone (5) and yucalexin P-21 (6). Compounds 1-5 were obtained from cassava for the first time. Antibacterial activity was assayed by paper disk diffusion method, and compounds 1,3,4, and 6 showed inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and S. aureus.