枝顶孢属真菌的抑菌活性及其代谢产物研究

Antibacterial Activity and Metabolits of an Acremonium Fungus

摘要:

用组织分离法从采集于广东鼎湖山的腐殖质中分离得到一株枝顶孢属真菌(Acremonium sp. SC0105),其固体发酵物的乙醇提取物对金黄色葡萄球菌(Staphylococcus aureus)有较强的抑制作用。经多种柱层析,从固体发酵物中分离得到5个化合物。通过光谱分析,分别鉴定为姜糖脂B (1)、姜糖脂C (2)、D-甘露醇(3)、酒渣碱(4)、枝顶孢素F(5)。其中酒渣碱是首次从枝顶孢属真菌中分离得到。

Abstract:

A fungal strain of Acremonium sp. SC0105 was obtained from tissue culture of humus collected at Dinghushan, Guangdong Province, China. The EtOH extract of this fungal strain showed antibacterial activity against Staphylococcus aureus. From the solid cultures of this fungus, five compounds were isolated by repeated column chromatography. On the basis of their spectral data, they were identified as gingerglycolipid B (1), gingerglycolipid C (2), D-Mannitol (3), flazine (4), and acremine F (5). Among them, flazine (4) was isolated from fungus of Acremonium genus for the first time.