红厚壳枝条的化学成分

Chemical Constituents from the Twigs of Calophyllum inophyllum Linn.

摘要:

从红厚壳(Calophyllum inophyllum Linn.)枝条乙醇提取物中分离得到11个化合物,通过光谱分析,鉴定其结构为:6-羟基-2,3-二甲氧基??酮 (1),1,3,7-三羟基??酮 (2),1,3,7-三羟基-8-甲氧基??酮(3),7-羟基-1,3-二甲氧基??酮(4),伪蒲公英甾醇(5),1,3,6-三羟基-5,7-二甲氧基??酮(6),2-羟基-1-甲氧基??酮 (7),2-羟基-1,8-二甲氧基??酮 (8),1,3,5-三羟基-2-甲氧基??酮 (9),4-羟基??酮 (10),1,3,5-三羟基??酮 (11) 。化合物 2 ~ 5 为首次从红厚壳属植物中得到,化合物 6 ~ 8 为首次从该植物中得到,化合物 1 为一新的天然产物。细胞毒活性测试结果表明,化合物 9 对人胃癌细胞(SGC-7901)的增殖显示出生长抑制活性, 其IC₅₀值为1.8×10^-5 mol/L。

Abstract:

Eleven compounds were extracted from EtOH extract of the twigs of Calophyllum inophyllum. On the basis of spectroscopic data, their structures were identified as 6-hydroxy-2,3-dimethoxyxanthone (1), 1,3,7-trihydroxylxanthone (2), 1,3,7-trihydroxy-8-methoxyxanthone (3), 7-hydroxy-1,3-dimethoxyxanthone (4), pseudo taraxasterol (5), 1,3,6-trihydroxy-5,7-dimethoxyxanthone (6), 2-hydroxy-1-methoxy-xanthone (7), 2-hydroxy-1,8-dimethoxyxanthone (8), 1,3,5-trihydroxy-2-methoxyxanthone (9), 4-hydroxyxanthone (10), and 1,3,5-trihydroxyxanthone (11) . Compounds 6-8 were isolated from this plant for the first time, and compounds 2-5 from the genus Calophyllum for the first time. Compound 1 was a new natural product. Compound 9 showed inhibitory activities towards human gastric carcinoma (SGC-7901), with the IC₅₀ value of 1.8×10^-5 mol/L.