白木香内生真菌Fimetariella rabenhorstii的甾体类代谢产物

Steroidal Metabolites of Fimetariella rabenhorstii, Endophytic Fungus from Aquilaria sinensis

摘要:

从白木香(Aquilaria sinensis (Lour.) Gilg)内生真菌Fimetariella rabenhorstii A20的发酵菌丝体中分离得到4个甾体类化合物。通过波谱分析，分别鉴定为5α,8α-桥氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇(1)、3β,6β,7α-三羟基-(24R)麦角甾-8(14),22-二烯(2)、3β,5α,9α-三羟基-(22E,24R)-麦角甾-7,22-二烯-6-酮(3)和3β,5α,6β-三羟基-(22E,24R)-麦角甾-7,22-二烯(4)。这些化合物均为首次从Fimetariella属真菌中分离获得。

Abstract:

Four steroids were isolated from the fermented mycelia of F. rabenhorstii A20, an endophytic fungus from Aquilaria sinensis (Lour.) Gilg. On the basis of spectral data, they were identified as 5α,8α-epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (1), 3β,6β,7α-trihydroxy- (24R)-ergosta-8(14),22-diene (2), 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (3), and 3β,5α,6β-trihydroxy-(22E,24R)-ergosta-7,22-diene (4). All compounds were isolated from the genus Fimetariella for the first time.