细花线纹香茶菜的化学成分研究

Chemical Constituents from Isodon lophanthoides var. graciliflora

摘要:

用色谱技术对细花线纹香茶菜(Isodon lophanthoides var. graciliflora)全草水提物进行分离纯化，获得了11种单体化合物。通过光谱分析及与文献数据对照，分别鉴定为牡荆素(vitexin, 1)、藿香黄酮醇(pachypodol, 2)、猫眼草黄素(chrysoplenetin, 3)、9-羟基-5,7-豆甾二烯-4-酮(9-hydroxy-5,7-megastigmadien-4-one, 4)、3,9-二羟基-5,7-豆甾二烯-4-酮(3,9-dihydroxy-5,7-megastigmadien-4-one, 5)、黑麦草内酯(loliolide, 6)、4-乙酰-5-甲基二氢呋喃-2-酮(4-acetyl-5-methyldihydrofuran-2-one, 7)、5-羟甲基糠醛(5-hydroxymethylfuraldehyde, 8)、5-甲氧甲基-1H-吡咯-2-甲醛(5-methoxymethyl-1H-pyrrole-2-carbaldehyde, 9)、3-吲哚甲醛(indole-3-aldehyde, 10)和丁二酸单丁酯(succinic acid monobutyl ester, 11)。这些化合物均为首次从线纹香茶菜中分离得到。

Abstract:

The aqueous extract from the whole plant of Isodon lophanthoides var. graciliflora was separated and purified by means of chromatographic technology and eleven compounds were isolated. On the basis of spectral data, they were identified as vitexin (1), pachypodol (2), chrysoplenetin (3), 9-hydroxy-5,7-megastigmadien-4-one (4), 3,9-dihydroxy-5,7-megastigmadien-4-one (5), loliolide (6), 4-acetyl-5-methyldihydrofuran-2-one (7), 5-hydroxymethylfuraldehyde (8), 5-methoxymethyl-1H-pyrrole-2-carbaldehyde (9), indole-3-aldehyde (10), and succinic acid monobutyl ester (11). All the compounds were obtained from Isodon lophanthoides for the first time.