巴东过路黄中三萜皂苷及其体外抗肿瘤活性研究

Triterpenoid saponins from Lysimachia patungensis and their anti-tumor activities in vitro

摘要:

从巴东过路黄提取物的正丁醇萃取部位中，分离到2个齐墩果烷型三萜皂苷，经光谱鉴定，分别为ardicrenin(1)和ardisiacrispin A(2)。体外抗肿瘤实验显示ardicrenin(1)对人脑胶质瘤(SWO-38)、口腔上皮癌(KB)、人乳腺癌(MCF-7)和人宫颈癌(Hela)细胞的半数毒性浓度(TC₅₀)分别为3.16、3.16、2.97、2.42 μmol/L，Ardisiacrispin A(2)对上述细胞的TC₅₀分别为3.96、3.01、1.98、2.73 μmol/L。

Abstract:

Two triterpenoid saponins, characterized by the oleanane-derived sapogenol, were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz., and their structures were established as ardicrenin (1) and ardisiacrispin A (2) by spectral data. The TC₅₀s of ardicrenin (1) against cell lines SWO-38, KB , MCF-7 and Hela in vitro were 3.16, 3.16, 2.97, 2.42 μmol/L, respectively, and those of ardisiacrispin A (2) against the cell lines were 3.96, 3.01, 1.98, 2.73 μmol/L, respectively.