华麻花头根中的神经酰胺成分

Ceramides from the Roots of Serratula chinensis

摘要:

从菊科麻花头属植物华麻花头（Serratula chinensis S．Moore）根中分离得一组神经酰胺类化俞物，经光谱和化学方法分析，鉴定为（2S，3S，4R，8E）-8，9-二脱氢植物鞘氨醇（2R）-2-羟基脂肪酰胺，其脂肪酸链主要由十六，二十二，二十三，二十四和二十五烷酸组成，其中2-羟基十六碳酸组成的神经酰胺（2S，3S，4R，8E）-2-[（2R）-2-羟基棕榈酰胺]-8-十八碳烯-1，3，4-三醇为一新化合物。高锰酸钾氧化法被应用于判断单不饱和长链中双键的化置。

Abstract:

A mixture of five ceramides was isolated from the roots ofSerratula chinensis （Compositae）. The structures of these compounds were elucidated as （2S, 3S, 4R, 8E）-2-amino-8-octadecene-1, 3, 4-triol with five 2-hydroxy fatty acids of varying chain lengths （C₁₆, C_22-25） linked to the amino group （1a-1e, respectively）. Ceramide la was a new compound. The structures were established by spectroscopic and chemical means. The KMnO₄ oxidation method was applied to locate the double bond position in monounsaturated long chain bases.